What I Wish I’d Known About GLP-1 Side Effects

What I Wish I’d Known About GLP-1 Side Effects


Semaglutide erased the fixed psychological chatter about meals that had dominated her life, however together with it went her consciousness of primary wants.

Author Kristen Reed's before and after pictures for her GLP-1 weight loss journeyShare on Pinterest
Author Kristen Reed shares her weight reduction journey with compounded semaglutide. Images courtesy of Kristen Reed

Well being and wellness contact everybody’s life otherwise. That is one particular person’s story. The views and opinions expressed are these of the speaker and don’t essentially replicate the views or positions of Healthline Media.

It hit me at a Mexican restaurant. The chips and salsa have been on the desk — heat, salty, scrumptious — and after having fun with just some, I used to be accomplished. Not as a result of I used to be being “good” or disciplined, however as a result of I used to be happy.

Previously, I’d have eaten my technique to the underside of the basket. Then it dawned on me: the meals noise was gone.

Six months earlier than that chips-and-salsa second, I began taking compounded semaglutide after leaving an abusive marriage and studying my A1C was nearing prediabetic. The following 16 months reshaped my physique and my relationships with meals, my children, and myself.

The “meals noise” disappeared, however so did my consciousness of some primary wants. As an example, I’d overlook to drink water and prepare dinner meals for my children.

I had realized the arduous means that you just want medical oversight when taking GLP-1 drugs, which I’d obtained compounded versions of by way of medical professionals at an area medspa and a compounding pharmacy.

I weighed 180 kilos once I began GLP-1 medication in November 2023and stopped at 135 kilos in July 2025.

If I may return to that first shot of semaglutide, I’d know I’d want a timeline and an exit technique. I’d additionally know that I’d want group assist from individuals who perceive this explicit weight loss journey. I don’t remorse taking GLP-1 medication, however right here’s what I want I’d identified earlier than beginning them.

Earlier than I began GLP-1s, food noise was a continuing way of thinking.

My ideas swirled across the subsequent snack or meal as in the event that they have been an in depth companion. Meals noise was ever-present after which, surprisingly and immediately, absent.

One surprising casualty was my baking interest. Just a few months into my weight reduction journey, I finished baking. The will merely dissipated.

Earlier than I began the injections, I’d been on a pound cake kick, baking weekly only for the enjoyable of it. In hindsight, meals noise could have been driving the interest, although I actually loved the method of baking.

In some unspecified time in the future, I simply stopped baking and didn’t appear to overlook it. The meals noise that’d prompted weekly fixes for pound truffles was gone. The absence of that noise — the silence, actually — was deafening.

Because the psychological chatter round meals quieted, I noticed I had missed different indicators my physique was sending. Painful constipation compelled me to confront how little water I used to be consuming. Seems dehydration could be a aspect impact of GLP-1 medication.

I spoke with Mir B. Ali, MD, a bariatric surgeon and medical director of the MemorialCare Surgical Weight Loss Heart at Orange Coast Medical Heart in California, to realize a greater understanding of what occurred.

He defined that the medicine slows your digestive system. That slowdown, mixed with even delicate dehydration, can create intense constipation.

Ali advises his sufferers to drink water and different non-sugary liquids all through the day, aiming for 48 ounces. Extreme dehydration is uncommon with GLP-1 use, he stated, however the issue is extra refined.

“Sufferers simply overlook to drink, and you’ll’t gulp a complete bunch directly as a result of your abdomen is emptying slower, and it’d make you nauseous,” Ali stated.

That was my expertise. I merely forgot to drink water.

Staying hydrated is about greater than avoiding discomfort. Research means that chronic dehydration may cause critical well being dangers as we age. Once you overlook to eat or drink, these dangers can accumulate silently.

So, I tracked my water bottle refills, generally including electrolyte powders. My dehydration wasn’t simply an uncomfortable aspect impact. It had the potential to derail the whole lot I labored towards. This is able to have been useful to know up entrance.

Docs advise folks taking GLP-1 medication — and most of the people basically — to train no less than half-hour every day.

Common train helps your physique keep metabolism and muscle, that are each in danger whereas taking GLP-1 medication.

Nonetheless, I’d misplaced the motivation to train. After I began taking GLP-1s, I discovered I had little or no power. At occasions, I may barely summon the power for even probably the most mundane duties, reminiscent of answering an e-mail, folding laundry, or taking my toddler to the playground.

Exercising undoubtedly wasn’t going to occur, which was complicated since I’d at all times been athletic and liked being energetic.

After I requested Ali about this, he stated he wasn’t stunned. He defined that the physique has much less power when it’s burning calories. I additionally realized I probably wasn’t consuming sufficient protein.

“When sufferers are low in power, they’re in all probability not getting sufficient protein. Protein is important for muscle preservation, in addition to for common power wants. So, we emphasize protein and greens within the eating regimen and decreasing carbohydrate consumption,” Ali stated. “That type of directs your physique towards burning fats extra.”

I routinely forgot to prepare dinner meals for my children. Choose me in the event you should, however I used to be not often fascinated with meals for myself, not to mention anybody else.

I’ve a teen and a toddler who’d get dwelling and ask, “What’s for dinner?” and I’d be like, “Oh, proper, dinner!” I felt responsible as a result of meals was so removed from my thoughts, however my children nonetheless wanted to eat.

I keep in mind my 2-year-old opening the freezer one night and pulling out a bag of frozen greens. That good child was telling me she was prepared for dinner. Ouch. I ready a fast meal and she or he devoured the entire thing. That evening, I noticed I wanted higher methods in place to stop this from occurring once more.

I relied on air-fryer meals for my toddler and inspired my teen to prepare dinner, which labored out nice as a result of he enjoys being within the kitchen — however not the half the place he has to do the dishes. We additionally ordered takeout fairly a bit.

Cooking for my children jogged my memory that I nonetheless needed to eat, too.

My weight plateaued for months, so my main care doctor (who didn’t prescribe my semaglutide injections) really helpful I cease chilly turkey. In hindsight, I ought to have deliberate an exit technique.

There was no dramatic shift. My appetite returned regularly, nearly imperceptibly. Just a little extra curiosity in meals one week, a basket of tortilla chips the following. 5 months handed, and 10 kilos returned. I keep in mind taking a look at trip photos and realizing my hard-earned physique was slipping away.

I made a decision to attempt semaglutide once more, however I knew I couldn’t simply restart the injections and count on totally different outcomes.

On many days, I ate one meal a day. Nonetheless, this consuming sample was setting the stage for a probably harmful aspect impact. I merely wasn’t getting sufficient vitamin.

My nails have been brittle, and my beautician observed my hair was dry and weak, chopping off two inches of what seemed like straw on the salon ground. I blamed work stress.

I discussed it casually throughout my annual bodily, prompting my physician to ask questions like: What was I consuming every day? Was I monitoring protein? How typically was I really consuming?

My physician wasn’t managing my GLP-1 remedy; I did my very own factor whereas conserving her knowledgeable. However she related the dots I missed. The hair loss, brittle nails, and my eating regimen: we suspected malnutrition.

I finished the compounded medicine at 135 kilos, which was 5 lbs from my goal. I set the goal weight low as a result of expertise taught me I’d probably settle at a better weight as soon as off the meds.

I later realized that malnutrition whereas taking GLP-1s is uncommon. Ali stated that what I skilled may have been triggered by a hormonal shift ensuing from speedy weight reduction.

I realized you want somebody watching greater than the size — a medical skilled who can see patterns you’re too shut to acknowledge. Weight reduction was by no means alleged to be the one metric that mattered.

My girlfriends have been on GLP-1 medication earlier than me, and understood the expertise in methods analysis couldn’t seize.

We rapidly grew to become one another’s sounding board at totally different levels on totally different medicines and with totally different targets, like weight regain once I plateaued.

We traded sensible methods: Pepto-Bismol capsules earlier than injections helped alleviate nausea, intermittent fasting worked for upkeep, and lengthy walks have been simpler when accomplished collectively. The information helped, however that wasn’t the true present.

This group gave me permission. After years in survival mode, I wanted to see girls prioritizing themselves — taking on area, investing money and time, asking for what they wanted. They confirmed me what that seemed like. Watching them confirmed me I used to be allowed to need it, too.

I’ve been off semaglutide since August and am sustaining my new wholesome weight.

For me, intermittent fasting, deliberate daily movement, and a balanced eating regimen wealthy in protein and fiber assist me keep robust, wholesome, and motivated. I nonetheless select solely the carbs price consuming — good bread, not mediocre bread.

And the meals noise? Nicely, it’s again, however I’m keenly conscious of it now. After I open the pantry, I pause and ask: Does my physique really really feel hungry proper now? Typically the reply is not any, and I eat anyway.

However the distinction is the pause. The notice. The selection.

GLP-1 didn’t treatment my relationship with food — it gave me the silence I wanted to start out listening to my physique once more after years of survival mode had skilled me to disregard it.

Now, once I sit down at that Mexican restaurant, the chips and salsa in entrance of me, I don’t at all times make the selection to be “good,” however in that cut up second between impulse and motion — I make a alternative.

That little second of company earlier than my hand reaches my mouth is the present I’m going to carry onto.



Source link