- An actual-world examine discovered that individuals with sort 2 diabetes who elevated their Ozempic dose slightly than switching to Mounjaro had a decrease danger of main opposed cardiovascular occasions (MACE).
- Those that elevated their Ozempic dose to 2 mg had a 6% decrease danger of MACE than those that switched to Mounjaro.
- As a result of the examine was observational, it confirmed an affiliation and doesn’t show that rising the Ozempic dose induced the decrease cardiovascular danger.
It is very important understand that this was a retrospective, observational examine that confirmed an affiliation, not causation.
Extra analysis is required to totally evaluate the cardiovascular advantages of semaglutide versus tirzepatide.
The COMPETE SWITCH Cardiovascular (CV) evaluation used Komodo Well being’s Healthcare Map, a big US healthcare claims database with linked laboratory outcomes, to look at real-world information from 636,525 adults with sort 2 diabetes.
The evaluation targeted on 185,705 individuals who elevated their semaglutide dose and 23,104 who switched to tirzepatide.
All individuals included within the evaluation have been already receiving 1 mg of semaglutide (Ozempic) weekly.
- 67.2% remained on 1 mg of Ozempic
- 29.2% escalated to 2 mg of Ozempic
- 3.6% switched to tirzepatide (Mounjaro) inside 1 12 months of beginning the 1 mg Ozempic dose
On the 720-day follow-up:
- 57.4% remained on the 1 mg of Ozempic
- 36.9% escalated to 2 mg of Ozempic
- 5.7% switched to Mounjaro
The researchers discovered that individuals who elevated their Ozempic dose to 2 mg had a 6% decrease danger of MACE — together with all-cause loss of life, myocardial infarction (heart attack), and stroke — in contrast with those that switched to Mounjaro at doses as much as 15 mg.
“That is an fascinating examine, however the findings could partly mirror treatment adherence. When sufferers swap medicines, it may well take time to regulate the dose and discover the best remedy degree, which can briefly have an effect on how effectively their situation is managed,” mentioned Mir Ali, MD, medical director of MemorialCare Surgical Weight Loss Heart at Orange Coast Medical Heart in Fountain Valley, CA, who wasn’t concerned within the examine.
He additionally famous that the examine didn’t decide what would possibly clarify the distinction in cardiovascular danger.
“It could be associated to a mix of weight reduction and direct results on hormones concerned in metabolism and urge for food regulation,” Ali mentioned.
Semaglutide and tirzepatide are each GLP-1 medicines. Ozempic (semaglutide) and Mounjaro (tirzepatide) are authorised to assist handle sort 2 diabetes, whereas every treatment additionally has a unique model authorised for weight reduction.
“Semaglutide and tirzepatide work in an analogous approach. Whereas semaglutide is a direct
“As a result of they work via considerably totally different pathways, they will have totally different results in particular person sufferers,” added Ali.
Whereas each semaglutide (Ozemipc) and tirzepatide (Mounjaro) work in comparable methods, you could discover that you just tolerate one higher than the opposite.
Ali famous that you need to talk about any potential advantages and downsides together with your healthcare skilled.
“I’d solely advocate switching medicines if there is a matter with tolerance of 1 or the opposite. If one treatment is well-tolerated at more and more larger doses and is efficient within the desired weight-loss and blood sugar administration, I wouldn’t essentially swap,” added Blumfield.
- nausea and vomiting
- diarrhea
- constipation
- reactions on the injection web site
These unwanted side effects are typically gentle and should reduce over time. Nevertheless, if unwanted side effects grow to be tough to tolerate, you need to communicate together with your healthcare skilled.
“GLP-1 medicines could be extremely efficient for managing diabetes and selling weight reduction, however there is no such thing as a one-size-fits-all remedy. The very best treatment is dependent upon a person’s well being wants, objectives, response to remedy, and potential unwanted side effects,” mentioned Ali.
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